Molecular basis for the actions of Hsp90 inhibitors and cancer therapy
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology
Link
http://www.nature.com/articles/ja201160.pdf
Reference85 articles.
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3. Bedin, M., Gaben, A. M., Saucier, C. & Mester, J. Geldanamycin, an inhibitor of the chaperone activity of HSP90, induces MAPK-independent cell cycle arrest. Int. J. Cancer 109, 643–652 (2004).
4. Whitesell, L., Mimnaugh, E. G., De Costa, B., Myers, C. E. & Neckers, L. Inhibition of heat-shock protein HSP90–pp60v–src hetero-protein complex formation by benzoquinoid ansamycins. Proc. Natl. Acad. Sci. USA 91, 8324–8328 (1994).
5. Stebbins, C. E. et al. Crystal structure of an Hsp90–geldanamycin complex: targeting of a protein chaperone by an antitumor agent. Cell 89, 239–250 (1997).
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