Investigation of the biosynthesis of the pipecolate moiety of neuroprotective polyketide meridamycin
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology
Link
http://www.nature.com/articles/ja201145.pdf
Reference23 articles.
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2. Wilson, K. P. et al. Comparative X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and rapamycin. Acta. Crystallogr. D Biol. Crystallogr. 51, 511–521 (1995).
3. Broquist, H. P. Lysine-pipecolic acid metabolic relationships in microbes and mammals. Annu. Rev. Nutr. 11, 435–448 (1991).
4. He, M. Pipecolic acid in microbes: biosynthetic routes and enzymes. J. Ind. Microbiol. Biotechnol. 33, 401–407 (2006).
5. Khaw, L. E., Bohm, G. A., Metcalfe, S., Staunton, J. & Leadlay, P. F. Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase. J. Bacteriol. 180, 809–814 (1998).
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