Understanding transport through pharmacological barriers — are we there yet?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd3187-c1.pdf
Reference10 articles.
1. Sugano, K. et al. Coexistence of passive and carrier-mediated processes in drug transport. Nature Rev. Drug Discov. 9, 597–614 (2010).
2. Giacomini, K. M. et al. Membrane transporters in drug development. Nature Rev. Drug Discov. 9, 215–236 (2010).
3. Dobson, P. D. & Kell, D. B. Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? Nature Rev. Drug Discov. 7, 205–220 (2008).
4. Higgins, C. F. & Gottesman, M. M. Is the multidrug transporter a flippase? Trends Biochem. Sci. 17, 18–21 (1992).
5. Lipinski, C. A., Lombardo, F., Dominy, B. W. & Feeney, P. J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 46, 3–26 (2001).
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