A Mechanistic Model of Drug-Induced Liver Injury Aids the Interpretation of Elevated Liver Transaminase Levels in a Phase I Clinical Trial-Reference-Cited by-同舟云学术

A Mechanistic Model of Drug-Induced Liver Injury Aids the Interpretation of Elevated Liver Transaminase Levels in a Phase I Clinical Trial

Published:2014-02 Issue:2 Volume:3 Page:98
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT: Pharmacometrics & Systems Pharmacology

Author:

Howell BA¹,Siler SQ¹,Shoda LKM¹,Yang Y¹,Woodhead JL¹,Watkins PB¹²

Affiliation:

1. The Hamner-UNC Institute for Drug Safety Sciences, The Hamner Institutes, Research Triangle Park; North Carolina USA

2. School of Medicine and School of Pharmacy, University of North Carolina at Chapel Hill; Chapel Hill North Carolina USA

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1038/psp.2013.74/fullpdf

Reference28 articles.

1. US Food and Drug Administration New Drug and Biological Drug Products: Evidence Needed to Demonstrate Effectiveness of New Drugs When Human Efficacy Studies Are Not Ethical or Feasible http://www.gpo.gov/fdsys/pkg/FR-2002-05-31/pdf/02-13583.pdf 2002

2. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models;Burdelya;Science,2008

3. The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers;Harrill;Clin. Pharmacol. Ther.,2012

4. Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity;Antoine;J. Hepatol.,2012

5. Mathematical modeling of liver injury and dysfunction after acetaminophen overdose: early discrimination between survival and death;Remien;Hepatology,2012

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