Physiologically Based Pharmacokinetic Modeling Framework for Quantitative Prediction of an Herb-Drug Interaction

Author:

Brantley SJ1,Gufford BT2,Dua R1,Fediuk DJ1,Graf TN3,Scarlett YV4,Frederick KS5,Fisher MB6,Oberlies NH3,Paine MF2

Affiliation:

1. Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill; Chapel Hill North Carolina USA

2. College of Pharmacy, Washington State University; Spokane Washington USA

3. Department of Chemistry and Biochemistry; The University of North Carolina at Greensboro; Greensboro North Carolina USA

4. School of Medicine, The University of North Carolina at Chapel Hill; Chapel Hill North Carolina USA

5. Boehringer Ingelheim Pharmaceuticals, Inc.; Ridgefield Connecticut USA

6. ProPharma Services, LLC; Oxford Connecticut USA

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Reference48 articles.

1. Pharmacokinetic herb-drug interactions (part 1): origins, mechanisms, and the impact of botanical dietary supplements;Gurley;Planta Med,2012

2. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions;Hermann;Planta Med,2012

3. Botanical-drug interactions: a scientific perspective;Lima Toccafondo Vieira;Planta Med,2012

4. Clinical relevance of the small intestine as an organ of drug elimination: drug-fruit juice interactions;Paine;Expert Opin. Drug Metab. Toxicol,2007

5. European Medicines Agency Guideline on the Investigation of Drug Interactions 2012 http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2012/07/WC500129606.pdf

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