A Nonlinear Mixed Effects Pharmacokinetic Model for Dapagliflozin and Dapagliflozin 3-O -glucuronide in Renal or Hepatic Impairment
Author:
Affiliation:
1. Department of Pharmaceutical Biosciences; Uppsala University; Uppsala Sweden
2. Discovery Medicine and Clinical Pharmacology, Bristol-Myers Squibb; Princeton New Jersey USA
Publisher
Wiley
Subject
Pharmacology (medical),Modeling and Simulation
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1038/psp.2013.20/fullpdf
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2. Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus;Komoroski;Clin. Pharmacol. Ther.,2009
3. Simultaneous oral therapeutic and intravenous ¹4C-microdoses to determine the absolute oral bioavailability of saxagliptin and dapagliflozin;Boulton;Br. J. Clin. Pharmacol.,2013
4. Kasichayanula , S. et al Disposition and mass balance of [14C]-dapagliflozin after single oral doses in healthy male volunteers American Association of Pharmaceutical Scientists Atlanta, GA 2008
5. Diabetic nephropathy;Molitch;Diabetes Care,2003
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