White Paper: Landscape on Technical and Conceptual Requirements and Competence Framework in Drug/Disease Modeling and Simulation

Author:

Vlasakakis G1,Comets E2,Keunecke A3,Gueorguieva I4,Magni P5,Terranova N5,Della Pasqua O1,de Lange EC6,Kloft C3

Affiliation:

1. GSK, Clinical Pharmacology Modelling & Simulation; Stockley Park UK

2. INSERM, UMR 738 Univ Paris Diderot; Sorbonne Paris Cité Paris France

3. Department of Clinical Pharmacy and Biochemistry; Freie Universitaet Berlin; Berlin Germany

4. Global PK/PD Department; Erl Wood Manor, Lilly UK; Windlesham Surrey UK

5. Dipartimento di Ingegneria Industriale e dell'Informazione; Università degli Studi di Pavia; Pavia Italy

6. Leiden Academic Centre for Drug Research, Leiden University; Leiden The Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Reference30 articles.

1. CPT: pharmacometrics and systems pharmacology;Graaf;CPT Pharmacometrics Syst. Pharmacol.,2012

2. Diagnosing the decline in pharmaceutical R&D efficiency;Scannell;Nat. Rev. Drug Discov.,2012

3. Can the pharmaceutical industry reduce attrition rates?;Kola;Nat. Rev. Drug Discov.,2004

4. Model-based drug development;Lalonde;Clin. Pharmacol. Ther.,2007

5. Concepts and challenges in quantitative pharmacology and model-based drug development;Zhang;AAPS J.,2008

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