Systems Pharmacology Models Can Be Used to Understand Complex Pharmacokinetic-Pharmacodynamic Behavior: An Example Using 5-Lipoxygenase Inhibitors
Author:
Affiliation:
1. Institute for Systems Biology SPb; Moscow Russia
2. Clinical Pharmacology, Drug Metabolism, and Pharmacokinetics, MedImmune, LLC; Cambridge UK
3. Leiden Academic Centre for Drug Research (LACDR); Leiden Netherlands
Publisher
Wiley
Subject
Pharmacology (medical),Modelling and Simulation
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1038/psp.2013.49/fullpdf
Reference50 articles.
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3. The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate asthma;Israel;Ann. Intern. Med.,1993
4. Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group;Israel;JAMA,1996
5. Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach;Karelina;BMC Syst. Biol.,2012
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