Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer

Author:

Kim Dong Ha,Kim HyeongRyul,Choi Yun Jung,Kim Seon Ye,Lee Jung-Eun,Sung Ki Jung,Sung Young Hoon,Pack Chan-GiORCID,Jung Min-kyo,Han BuhmORCID,Kim Kunhee,Kim Woo Sung,Nam Soo Jeong,Choi Chang-Min,Yun Miyong,Lee Jae Cheol,Rho Jin Kyung

Funder

National Research Foundation of Korea

Ministry of Health and Welfare

Publisher

Springer Science and Business Media LLC

Subject

Clinical Biochemistry,Molecular Biology,Molecular Medicine,Biochemistry

Reference54 articles.

1. Siegel, R., Naishadham, D. & Jemal, A. Cancer statistics, 2012. CA Cancer J. Clin. 62, 10–29 (2012).

2. Chan, B. A. & Hughes, B. G. Targeted therapy for non-small cell lung cancer: current standards and the promise of the future. Transl. Lung Cancer Res. 4, 36–54 (2015).

3. Grigg, C. & Rizvi, N. A. PD-L1 biomarker testing for non-small cell lung cancer: truth or fiction? J. Immunother. Cancer 4, 48 (2016).

4. He, J., Hu, Y., Hu, M. & Li, B. Development of PD-1/PD-L1 pathway in tumor immune microenvironment and treatment for non-small cell lung cancer. Sci. Rep. 5, 13110 (2015).

5. Barber, D. L. et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439, 682–687 (2006).

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