Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

Author:

Caldas Carlos,Hahn Stephan A.,da Costa Luis T.,Redston Mark S.,Schutte Mieke,Seymour Albert B.,Weinstein Craig L.,Hruban Ralph H.,Yeo Charles J.,Kern Scott E.

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Reference25 articles.

1. Boring, C.C., Squires, T.S. & Tong, T. Cancer statistics, 1993. CA Cancer J. Clin. 43, 7–26 (1993).

2. Almoguerra, C. et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53, 549–554 (1988).

3. Hruban, R.H. et al. K-ras oncogene activation in adenocarcinomas of the human pancreas: a study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotlde hybridization. Am. J. Pathol. 143, 545–554 (1993).

4. Pellegata, S. et al. K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions. Cancer Res. 54, 1556–1560 (1994).

5. Redston, M.S. et al. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopoiymer tracts in DNA microdeletions. Cancer Res. 54, 3025–3033 (1994).

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