The Role of the Spleen in Ischemic Stroke-Reference-Cited by-同舟云学术

The Role of the Spleen in Ischemic Stroke

Published:2014-12-03 Issue:2 Volume:35 Page:186-187
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Pennypacker Keith R¹,Offner Halina²

Affiliation:

1. Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA

2. Department of Neurology and Anesthesiology, Oregon Health and Science University, Portland, Oregon, USA

Abstract

This opinion piece highlights the scientific literature reporting that the peripheral immune response to ischemic stroke originates from the spleen. Removal of the spleen not only reduces stroke-induced neurodegeneration but also cellular degeneration in the body's other tissues when exposed to ischemic conditions.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2014.212

Reference20 articles.

1. Role of Spleen-Derived Monocytes/Macrophages in Acute Ischemic Brain Injury

2. Experimental Stroke Induces Massive, Rapid Activation of the Peripheral Immune System

3. Splenic Atrophy in Experimental Stroke Is Accompanied by Increased Regulatory T Cells and Circulating Macrophages

4. The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling

5. Cord blood rescues stroke-induced changes in splenocyte phenotype and function

Cited by 41 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. GPR55 Inactivation Diminishes Splenic Responses and Improves Neurological Outcomes in the Mouse Ischemia/Reperfusion Stroke Model;Cells;2024-02-03

2. Time Dimension Influences Severity of Stroke and Heightened Immune Response in Mice;Translational Stroke Research;2023-12-13

3. Microglia-mediated inflammatory destruction of neuro-cardiovascular dysfunction after stroke;Frontiers in Cellular Neuroscience;2023-03-21

4. Neutrophil Heterogeneity and its Roles in the Inflammatory Network after Ischemic Stroke;Current Neuropharmacology;2023-03

5. Immune regulation based on sex differences in ischemic stroke pathology;Frontiers in Immunology;2023-01-30