Inducing Stroke in Aged, Hypertensive, Diabetic Rats-Reference-Cited by-同舟云学术

Inducing Stroke in Aged, Hypertensive, Diabetic Rats

Published:2010-01-13 Issue:4 Volume:30 Page:729-733
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Rewell Sarah SJ¹,Fernandez John A¹,Cox Susan F¹,Spratt Neil J¹,Hogan Lisa¹,Aleksoska Elena¹,van Raay Leena¹,Liberatore Gabriel T¹,Batchelor Peter E¹,Howells David W¹

Affiliation:

1. National Stroke Research Institute and University of Melbourne Department of Medicine, Austin Health, Heidelberg, Victoria, Australia

Abstract

Animal models of ischemic stroke often neglect comorbidities common in patients. This study shows the feasibility of inducing stroke by 2 h of thread occlusion of the middle cerebral artery in aged (56 week old) spontaneously hypertensive rats (SHRs) with both acute (2 weeks) and chronic (36 weeks) diabetes. After modifying the streptozotocin dosing regimen to ensure that old SHRs survived the induction of diabetes, few died after induction of stroke. Induction of stroke is feasible in rats with multiple comorbidities. Inclusion of such comorbid animals may improve translation from the research laboratory to the clinic.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2009.273

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