Noninvasive High-Speed Photoacoustic Tomography of Cerebral Hemodynamics in Awake-Moving Rats-Reference-Cited by-同舟云学术

Noninvasive High-Speed Photoacoustic Tomography of Cerebral Hemodynamics in Awake-Moving Rats

Published:2015-06-17 Issue:8 Volume:35 Page:1224-1232
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Tang Jianbo¹,Xi Lei¹,Zhou Junli²,Huang Hua¹,Zhang Tao¹,Carney Paul R¹²³⁴,Jiang Huabei¹

Affiliation:

1. J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, USA

2. Department of Pediatrics, University of Florida, Gainesville, Florida, USA

3. Department of Neurology, University of Florida, Gainesville, Florida, USA

4. Department of Neuroscience, University of Florida, Gainesville, Florida, USA

Abstract

We present a noninvasive method of photoacoustic tomography (PAT) for imaging cerebral hemodynamics in awake-moving rats. The wearable PAT (wPAT) system has a size of 15 mm in height and 33 mm in diameter, and a weight of ~ 8 g (excluding cabling). The wPAT achieved an imaging rate of 3.33 frames/s with a lateral resolution of 243 μm. Animal experiments were designed to show wPAT feasibility for imaging cerebral hemodynamics on awake-moving animals. Results showed that the cerebral oxy-hemoglobin and deoxy-hemoglobin changed significantly in response to hyperoxia; and, after the injection of pentylenetetrazol (PTZ), cerebral blood volume changed faster over time and larger in amplitude for rats in awake-moving state compared with rats under anesthesia. By providing a light-weight, high-resolution technology for in vivo monitoring of cerebral hemodynamics in awake-behaving animals, it will be possible to develop a comprehensive understanding on how activity alters hemodynamics in normal and diseased states.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2015.138

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