Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier

Author:

Muldoon Leslie L12,Alvarez Jorge I34,Begley David J54,Boado Ruben J64,del Zoppo Gregory J74,Doolittle Nancy D14,Engelhardt Britta84,Hallenbeck John M94,Lonser Russell R104,Ohlfest John R114,Prat Alexandre34,Scarpa Maurizio124,Smeyne Richard J134,Drewes Lester R14,Neuwelt Edward A11516

Affiliation:

1. Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA

2. Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, Oregon, USA

3. Department of Medicine and Neurology, Center for Excellence in Neuromics, CRCHUM-Université de Montréal, Hôpital Notre-Dame, Montreal, Quebec, Canada

4. Contributing authors are listed in alphabetical order.

5. King's College London, Institute of Pharmaceutical Science, London, UK

6. Department of Medicine, University of California Los Angeles, Los Angeles, California, USA

7. Department of Medicine and Neurology, University of Washington, Seattle, Washington, USA

8. Theodor Kocher Institute, University of Bern, Bern, Switzerland

9. Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA

10. Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA

11. Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA

12. Department of Pediatrics, University of Padova, Padova, Italy

13. Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA

14. Department of Biochemistry and Molecular Biology, University of Minnesota, Duluth, Minnesota, USA

15. Department of Neurosurgery, Oregon Health and Science University, Portland, Oregon, USA

16. Office of Research and Development, Department of Veterans Affairs Medical Center, Portland, Oregon, USA

Abstract

The brain is in many ways an immunologically and pharmacologically privileged site. The blood–brain barrier (BBB) of the cerebrovascular endothelium and its participation in the complex structure of the neurovascular unit (NVU) restrict access of immune cells and immune mediators to the central nervous system (CNS). In pathologic conditions, very well-organized immunologic responses can develop within the CNS, raising important questions about the real nature and the intrinsic and extrinsic regulation of this immune privilege. We assess the interactions of immune cells and immune mediators with the BBB and NVU in neurologic disease, cerebrovascular disease, and intracerebral tumors. The goals of this review are to outline key scientific advances and the status of the science central to both the neuroinflammation and CNS barriers fields, and highlight the opportunities and priorities in advancing brain barriers research in the context of the larger immunology and neuroscience disciplines. This review article was developed from reports presented at the 2011 Annual Blood-Brain Barrier Consortium Meeting.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3