The Fatty Acid Amide Hydrolase C385A Variant Affects Brain Binding of the Positron Emission Tomography Tracer [11C]CURB-Reference-Cited by-同舟云学术

The Fatty Acid Amide Hydrolase C385A Variant Affects Brain Binding of the Positron Emission Tomography Tracer [11C]CURB

Published:2015-06-03 Issue:8 Volume:35 Page:1237-1240
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Boileau Isabelle¹²³⁴⁵,Tyndale Rachel F³⁵⁶,Williams Belinda¹²³⁴,Mansouri Esmaeil¹²³⁴,Westwood Duncan J¹²³⁴⁷,Foll Bernard Le³⁵⁷⁶,Rusjan Pablo M⁴⁵,Mizrahi Romina³⁴⁵⁷,De Luca Vincenzo³⁵⁷,Zhou Qian⁶,Wilson Alan A³⁴,Houle Sylvain³⁴,Kish Stephen J²³⁴⁵⁷,Tong Junchao²³⁴⁵

Affiliation:

1. Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

2. Human Brain Lab, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

3. Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

4. Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

5. Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

6. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

7. Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada

Abstract

The common functional single-nucleotide polymorphism (rs324420, C385A) of the endocannabinoid inactivating enzyme fatty acid amide hydrolase (FAAH) has been associated with anxiety disorder relevant phenotype and risk for addictions. Here, we tested whether the FAAH polymorphism affects in vivo binding of the FAAH positron emission tomography (PET) probe [11C]CURB ([11C-carbonyl]-6-hydroxy-[1,10-biphenyl]-3-yl cyclohexylcarbamate (URB694)). Participants ( n = 24) completed one [11C]CURB/PET scan and were genotyped for rs324420. Relative to C/C (58%), A-allele carriers (42%) had 23% lower [11C]CURB binding ( λk3) in brain. We report evidence that the genetic variant rs324420 in FAAH is associated with measurable differences in brain FAAH binding as per PET [11C]CURB measurement.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2015.119

Reference15 articles.

1. Amygdala FAAH and anandamide: mediating protection and recovery from stress

2. The genetic basis of the endocannabinoid system and drug addiction in humans

3. FAAH genetic variation enhances fronto-amygdala function in mouse and human

4. A missense mutation in human fatty acid amide hydrolase associated with problem drug use

5. Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use

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