Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response

Author:

Calcinaghi Novella1,Jolivet Renaud1,Wyss Matthias T12,Ametamey Simon M3,Gasparini Fabrizio4,Buck Alfred2,Weber Bruno1

Affiliation:

1. Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland

2. PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland

3. Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Department of Chemistry and Applied Biosciences of ETH, Zurich, Switzerland

4. Novartis Institutes for Biomedical Research, Basel, Switzerland

Abstract

Activation of astrocytic metabotropic glutamate receptor 5 (mGluR5) is postulated to elicit calcium transients, triggering a chain of events that ultimately regulates cerebral blood flow by changing the tone of smooth muscle cells of nearby arterioles. Using concurrent in vivo optical imaging and determination of receptor occupancy with 11C-ABP688, we report here that blocking ∼80% of mGluR5 in vivo does not affect transient hemodynamic responses on brief whisker stimulations while transiently reducing neuronal activity as measured by voltage-sensitive dye imaging. Our results show that mechanisms other than activation of mGluR5 are required to trigger the initial hemodynamic response in normal physiological conditions.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Clinical Neurology,Neurology

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