Total Cerebral Blood Flow in Relation to Cognitive Function: The Rotterdam Scan Study-Reference-Cited by-同舟云学术

Total Cerebral Blood Flow in Relation to Cognitive Function: The Rotterdam Scan Study

Published:2008-06-25 Issue:10 Volume:28 Page:1652-1655
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Poels Mariëlle MF¹²,Ikram Mohammad Arfan¹,Vernooij Meike W¹²,Krestin Gabriel P²,Hofman Albert¹,Messen Wiro J²³,van der Lugt Aad²,Breteler Monique MB¹

Affiliation:

1. Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands

2. Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands

3. Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, The Netherlands

Abstract

Cerebral hypoperfusion has been associated with worse cognitive function. We investigated the association between cerebral blood flow and cognition and whether this association is independent of brain volume. In 892 participants, aged 60 to 91 years, of the population-based Rotterdam Scan study, we measured total cerebral blood flow (tCBF) and brain volume using magnetic resonance imaging. Lower tCBF was associated with worse information-processing speed, executive function, and global cognition. However, after correcting tCBF for brain volume, these associations disappeared. The association between tCBF and cognition may be mediated or confounded by brain atrophy. Future studies on tCBF should take into account brain atrophy.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2008.62

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