Cerebral Dynamics and Metabolism of Hyperpolarized [1-13C]pyruvate Using Time-Resolved MR Spectroscopic Imaging-Reference-Cited by-同舟云学术

Cerebral Dynamics and Metabolism of Hyperpolarized [1-13C]pyruvate Using Time-Resolved MR Spectroscopic Imaging

Published:2010-06-30 Issue:10 Volume:30 Page:1734-1741
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Hurd Ralph E¹,Yen Yi-Fen¹,Tropp James¹,Pfefferbaum Adolf²³,Spielman Daniel M⁴,Mayer Dirk²⁴

Affiliation:

1. Global Applied Science Laboratory, GE Healthcare, Menlo Park, California, USA

2. SRI International, Neuroscience Program, Menlo Park, California, USA

3. Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA

4. Department of Radiology, Stanford University, Stanford, California, USA

Abstract

Dynamic hyperpolarized [1-13C]pyruvate metabolic imaging in the normal anesthetized rat brain is demonstrated on a clinical 3-T magnetic resonance imaging scanner. A 12-second bolus injection of hyperpolarized [1-13C]pyruvate is imaged at a 3-second temporal resolution. The observed dynamics are evaluated with regard to cerebral blood volume (CBV), flow, transport, and metabolic exchange with the cerebral lactate pool. A model for brain [1-13C]lactate, based on blood–brain transport kinetics, CBV, and the observed pyruvate dynamics is described.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2010.93

Reference22 articles.

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