Small Vessel Disease and the Resting Functional Architecture of the Brain-Reference-Cited by-同舟云学术

Small Vessel Disease and the Resting Functional Architecture of the Brain

Published:2014-04-30 Issue:7 Volume:34 Page:1089-1090
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Stevens Robert D¹²³⁴,Hannawi Yousef¹²,Sair Haris⁴

Affiliation:

1. Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

3. Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

4. Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Abstract

Small vessel disease (SVD) is linked to cognitive impairment and dementia, yet little is known regarding functional activation in patients with SVD. Resting fMRI recordings suggest reduced connectivity in prefrontal, parietal and cingulate nodes and reciprocally increased connectivity in cerebellum, alterations which predicted neuropsychological test performance. Together with diffusion tensor tensor imaging studies, these data support of a model of disrupted connectivity as a systems-level approach to the cognitive disturbances seen in SVD.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2014.69

Reference17 articles.

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2. The Pathobiology of Vascular Dementia

3. Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging

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5. Characterization of White Matter Damage in Ischemic Leukoaraiosis with Diffusion Tensor MRI

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