Neurovascular Uncoupling under Mild Hypoxic Hypoxia: An EEG–fMRI Study in Rats-Reference-Cited by-同舟云学术

Neurovascular Uncoupling under Mild Hypoxic Hypoxia: An EEG–fMRI Study in Rats

Published:2012-07-25 Issue:10 Volume:32 Page:1853-1858
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Sumiyoshi Akira¹,Suzuki Hideaki²,Shimokawa Hiroaki²,Kawashima Ryuta¹

Affiliation:

1. Department of Functional Brain Imaging, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan

2. Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

Abstract

The effects of oxygen availability on neurovascular coupling were investigated using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), in addition to the monitoring of physiological parameters, in 16 α-chloralose-anesthetized rats. Mild hypoxic hypoxia (oxygen saturation=83.6±12.1%) induced significant reductions in fMRI responses ( P<0.05) to electrical stimulation in the forepaw, but EEG responses remained unchanged. In addition, the changes in oxygen saturation were linearly correlated with the changes in the fMRI responses. These data further emphasize the importance of oxygen availability, which may regulate neurovascular coupling via the oxygen-dependent enzymatic synthesis of messenger molecules.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2012.111

Reference26 articles.

1. Glial and neuronal control of brain blood flow

2. Effects of extravascular acidification and extravascular alkalinization on constriction and depolarization in rat cerebral arterioles in vitro

3. Cerebral blood flow and BOLD fMRI responses to hypoxia in awake and anesthetized rats

4. Coupling between somatosensory evoked potentials and hemodynamic response in the rat

5. Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease

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