Her2/neu extracellular domain shedding in uterine serous carcinoma: implications for immunotherapy with trastuzumab

Author:

Todeschini P,Cocco E,Bellone S,Varughese J,Lin K,Carrara L,Guzzo F,Buza N,Hui P,Silasi D-A,Ratner E,Azodi M,Schwartz P E,Rutherford T J,Pecorelli S,Santin A D

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference33 articles.

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2. Anido J, Scaltriti M, Bech Serra JJ, Santiago Josefat B, Todo FR, Baselga J, Arribas J (2006) Biosynthesis of tumourigenic HER2 C-terminal fragments by alternative initiation of translation. EMBO J 25: 3234–3244

3. Baselga J, Carbonell X, Castañeda-Soto NJ, Clemens M, Green M, Harvey V, Morales S, Barton C, Ghahramani P (2005) Phase II study of efficacy, safety, and pharmacokinetics of trastuzumab monotherapy administered on a 3-weekly schedule. J Clin Oncol 23: 2162–2171

4. Bethune-Volters A, Labroquere M, Guepratte S, Hacene K, Neumann R, Carney W, Pichon MF (2004) Longitudinal changes in serum HER-2/neu oncoprotein levels in trastuzumab-treated metastatic breast cancer patients. Anticancer Res 24: 1083–1089

5. Brodowicz T, Wiltschke C, Budinsky AC, Krainer M, Steger GG, Zielinski CC (1997) Soluble HER-2/neu neutralizes biologic effects of anti-HER-2/neu antibody on breast cancer cells in vitro. Int J Cancer 73: 875–879

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