Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology-Reference-Cited by-同舟云学术

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Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

Published:2008-06 Issue:6 Volume:14 Page:681-687
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Town Terrence,Laouar Yasmina,Pittenger Christopher,Mori Takashi,Szekely Christine A,Tan Jun,Duman Ronald S,Flavell Richard A

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm1781.pdf

Reference30 articles.

1. Selkoe, D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81, 741–766 (2001).

2. Li, M.O., Wan, Y.Y., Sanjabi, S., Robertson, A.K. & Flavell, R.A. Transforming growth factor-β regulation of immune responses. Annu. Rev. Immunol. 24, 99–146 (2006).

3. Laouar, Y., Sutterwala, F.S., Gorelik, L. & Flavell, R.A. Transforming growth factor-β controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. Nat. Immunol. 6, 600–607 (2005).

4. Hsiao, K. et al. Correlative memory deficits, Aβ elevation and amyloid plaques in transgenic mice. Science 274, 99–102 (1996).

5. Akiyama, H. et al. Inflammation and Alzheimer's disease. Neurobiol. Aging 21, 383–421 (2000).

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