Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety-Reference-Cited by-同舟云学术

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Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety

Published:2010-04-29 Issue:6 Volume:24 Page:1160-1170
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Hoyos V,Savoldo B,Quintarelli C,Mahendravada A,Zhang M,Vera J,Heslop H E,Rooney C M,Brenner M K,Dotti G

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/leu201075.pdf

Reference51 articles.

1. Till BG, Jensen MC, Wang J, Chen EY, Wood BL, Greisman HA et al. Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells. Blood 2008; 112: 2261–2271.

2. Hombach A, Heuser C, Sircar R, Tillmann T, Diehl V, Pohl C et al. Characterization of a chimeric T-cell receptor with specificity for the Hodgkin's lymphoma-associated CD30 antigen. J Immunother 1999; 22: 473–480.

3. Sadelain M, Brentjens R, Riviere I . The promise and potential pitfalls of chimeric antigen receptors. Curr Opin Immunol 2009; 21: 215–223.

4. Savoldo B, Rooney CM, Di Stasi A, Abken H, Hombach A, Foster AE et al. Epstein Barr virus specific cytotoxic T lymphocytes expressing the anti-CD30{zeta} artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease. Blood 2007; 110: 2620–2630.

5. Dotti G, Savoldo B, Brenner M . Fifteen years of gene therapy based on chimeric antigen receptors: ‘are we nearly there yet?’. Hum Gene Ther 2009; 20: 1229–1239.

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