The sequence of application of methotrexate and histone deacetylase inhibitors determines either a synergistic or an antagonistic response in childhood acute lymphoblastic leukemia cells-Reference-Cited by-同舟云学术

The sequence of application of methotrexate and histone deacetylase inhibitors determines either a synergistic or an antagonistic response in childhood acute lymphoblastic leukemia cells

Published:2010-11-12 Issue:2 Volume:25 Page:359-361
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Bastian L,Einsiedel H G,Henze G,Seeger K,Shalapour S

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/leu2010259.pdf

Reference8 articles.

1. Leclerc GJ, Mou C, Leclerc GM, Mian AM, Barredo JC . Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy. Leukemia 2010; 24: 552–562.

2. Einsiedel HG, Kawan L, Eckert C, Witt O, Fichtner I, Henze G et al. Histone deacetylase inhibitors have antitumor activity in two NOD/SCID mouse models of B-cell precursor childhood acute lymphoblastic leukemia. Leukemia 2006; 20: 1435–1436.

3. Webb JL . Effect of More than One Inhibitor. Enzymes and Metabolic Inhibitors, vol. 1. Academic Press: New York, 1963, pp 66–79 and 487–512.

4. Kano Y, Akutsu M, Tsunoda S, Izumi T, Kobayashi H, Mano H et al. Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines. Invest New Drugs 2007; 25: 31–40.

5. Prasad P, Vasquez H, Das CM, Gopalakrishnan V, Wolff JE . Histone acetylation resulting in resistance to methotrexate in choroid plexus cells. J Neurooncol 2009; 91: 279–286.

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