Robust in vivo differentiation of t(8;21)-positive acute myeloid leukemia blasts to neutrophilic granulocytes induced by treatment with dasatinib-Reference-Cited by-同舟云学术

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Robust in vivo differentiation of t(8;21)-positive acute myeloid leukemia blasts to neutrophilic granulocytes induced by treatment with dasatinib

Published:2010-09-02 Issue:10 Volume:24 Page:1779-1781
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Chevalier N,Solari M L,Becker H,Pantic M,Gärtner F,Maul-Pavicic A,Hübner J,Wäsch R,Schmitt-Gräff A,Lübbert M

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/leu2010151.pdf

Reference16 articles.

1. Nowak D, Stewart D, Koeffler HP . Differentiation therapy of leukemia: 3 decades of development. Blood 2009; 113: 3655–3665.

2. Becker H, Pfeifer D, Afonso JD, Nimer SD, Veelken H, Schwabe M et al. Two cell lines of t(8;21) acute myeloid leukemia with activating KIT exon 17 mutation: models for the ‘second hit’ hypothesis. Leukemia 2008; 22: 1792–1794.

3. Schittenhelm MM, Shiraga S, Schroeder A, Corbin AS, Griffith D, Lee FY et al. Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res 2006; 66: 473–481.

4. Paschka P, Marcucci G, Ruppert AS, Mrozek K, Chen H, Kittles RA et al. Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study. J Clin Oncol 2006; 24: 3904–3911.

5. Müller AM, Duque J, Shizuru JA, Lübbert M . Complementing mutations in core binding factor leukemias: from mouse models to clinical applications. Oncogene 2008; 27: 5759–5773.

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