Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/nature07187.pdf
Reference35 articles.
1. de Rooij, J. et al. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396, 474–477 (1998)
2. Kawasaki, H. et al. A family of cAMP-binding proteins that directly activate Rap1. Science 282, 2275–2279 (1998)
3. Bos, J. L. Linking Rap to cell adhesion. Curr. Opin. Cell Biol. 17, 123–128 (2005)
4. Seino, S. & Shibasaki, T. PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. Physiol. Rev. 85, 1303–1342 (2005)
5. Rehmann, H., Das, J., Knipscheer, P., Wittinghofer, A. & Bos, J. L. Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state. Nature 439, 625–628 (2006)
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