Building antibody diversity
Author:
Publisher
Springer Science and Business Media LLC
Subject
Immunology,Immunology and Allergy
Link
http://www.nature.com/articles/ni.3609.pdf
Reference9 articles.
1. Alt, F. et al. Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: rearrangement of heavy but not light chain genes. Cell 27, 381–390 (1981)
2. Edelman, G. M. & Gally, J. A. Somatic recombination of duplicated genes: an hypothesis on the origin of antibody diversity. Proc. Natl. Acad. Sci. USA 57, 353–358 (1967)
3. Hozumi, N. & Tonegawa, S. Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc. Natl. Acad. Sci. USA 73, 3628–3632 (1976)
4. McBlane, J. F. et al. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83, 387–395 (1995)
5. Oettinger, M.A. et al. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248, 1517–1523 (1990)
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