Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery-Reference-Cited by-同舟云学术

Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery

Published:2014-03-16 Issue:4 Volume:32 Page:356-363
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Lee E-Chiang,Liang Qi,Ali Hanif,Bayliss Luke,Beasley Alastair,Bloomfield-Gerdes Tara,Bonoli Laura,Brown Richard,Campbell Jamie,Carpenter Adam,Chalk Sara,Davis Alison,England Nick,Fane-Dremucheva Alla,Franz Bettina,Germaschewski Volker,Holmes Helen,Holmes Steve,Kirby Ian,Kosmac Miha,Legent Anais,Lui Hui,Manin Anais,O'Leary Siobhan,Paterson Jemima,Sciarrillo Rocco,Speak Anneliese,Spensberger Dominik,Tuffery Laura,Waddell Nikole,Wang Wei,Wells Sophie,Wong Vivian,Wood Andrew,Owen Michael J,Friedrich Glenn A,Bradley Allan

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/nbt.2825.pdf

Reference35 articles.

1. Beck, A., Wurch, T., Bailly, C. & Corvaia, N. Strategies and challenges for the next generation of therapeutic antibodies. Nat. Rev. Immunol. 10, 345–352 (2010).

2. Neuberger, M.S. et al. Diversification and selection mechanisms for the production of protein repertoires: lessons from the immune system. Appl. Biochem. Biotechnol. 83, 53–62 (2000).

3. Lonberg, N. Human antibodies from transgenic animals. Nat. Biotechnol. 23, 1117–1125 (2005).

4. Lee, E.C. & Owen, M. The application of transgenic mice for therapeutic antibody discovery. Methods Mol. Biol. 901, 137–148 (2012).

5. Reichert, J.M. Marketed therapeutic antibodies compendium. MAbs 4, 413–415 (2012).

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