Experimental approaches to the study of HIV-1 latency-Reference-Cited by-同舟云学术

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Experimental approaches to the study of HIV-1 latency

Published:2007-02 Issue:2 Volume:5 Page:95-106
ISSN:1740-1526
Container-title:Nature Reviews Microbiology
language:en
Short-container-title:Nat Rev Microbiol

Author:

Han Yefei,Wind-Rotolo Megan,Yang Hung-Chih,Siliciano Janet D.,Siliciano Robert F.

Publisher

Springer Science and Business Media LLC

Subject

General Immunology and Microbiology,Microbiology,Infectious Diseases

Link

http://www.nature.com/articles/nrmicro1580.pdf

Reference117 articles.

1. Piatak, M. Jr et al. High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 259, 1749–1754 (1993).

2. Chun, T. W. et al. In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency. Nature Med. 1, 1284–1290 (1995). This paper provides the first in vivo evidence for the existence of a latent reservoir of HIV-1 in resting CD4+ T cells.

3. Chun, T. W. et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 387, 183–188 (1997). This paper presents a detailed analysis of the frequency of latently infected cells as measured by DNA PCR, inverse PCR and culture assays. Much of the subsequent development of assays for latently infected cells was based on this study.

4. Finzi, D. et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278, 1295–1300 (1997).

5. Chun, T. W. et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc. Natl Acad. Sci. USA 94, 13193–13197 (1997).

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