Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
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Published:2017-07-12
Issue:1
Volume:8
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Willems Sara M., , Wright Daniel J.ORCID, Day Felix R.ORCID, Trajanoska Katerina, Joshi Peter K.ORCID, Morris John A.ORCID, Matteini Amy M., Garton Fleur C., Grarup NielsORCID, Oskolkov Nikolay, Thalamuthu Anbupalam, Mangino MassimoORCID, Liu Jun, Demirkan Ayse, Lek Monkol, Xu Liwen, Wang Guan, Oldmeadow Christopher, Gaulton Kyle J.ORCID, Lotta Luca A., Miyamoto-Mikami Eri, Rivas Manuel A., White TomORCID, Loh Po-Ru, Aadahl Mette, Amin Najaf, Attia John R., Austin Krista, Benyamin Beben, Brage Søren, Cheng Yu-Ching, Cięszczyk Paweł, Derave Wim, Eriksson Karl-Fredrik, Eynon NirORCID, Linneberg AllanORCID, Lucia Alejandro, Massidda MyosotisORCID, Mitchell Braxton D., Miyachi MotohikoORCID, Murakami Haruka, Padmanabhan Sandosh, Pandey Ashutosh, Papadimitriou Ioannis, Rajpal Deepak K., Sale Craig, Schnurr Theresia M.ORCID, Sessa Francesco, Shrine NickORCID, Tobin Martin D.ORCID, Varley Ian, Wain Louise V.ORCID, Wray Naomi R., Lindgren Cecilia M., MacArthur Daniel G., Waterworth Dawn M., McCarthy Mark I., Pedersen Oluf, Khaw Kay-Tee, Kiel Douglas P., Pitsiladis Yannis, Fuku Noriyuki, Franks Paul W., North Kathryn N., van Duijn Cornelia M., Mather Karen A., Hansen Torben, Hansson OlaORCID, Spector Tim, Murabito Joanne M., Richards J. Brent, Rivadeneira FernandoORCID, Langenberg Claudia, Perry John R. B., Wareham Nick J., Scott Robert A.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference69 articles.
1. Bohannon, R. W. Hand-grip dynamometry predicts future outcomes in aging adults. J. Geriatr. Phys. Ther. 31, 3–10 (2008). 2. Taekema, D. G., Gussekloo, J., Maier, A. B., Westendorp, R. G. J. & de Craen, A. J. M. Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old. Age Ageing 39, 331–337 (2010). 3. Rantanen, T. et al. Muscle strength as a predictor of onset of ADL dependence in people aged 75 years. Aging Clin. Exp. Res. 14, 10–15 (2002). 4. Cheung, C.-L. et al. Low handgrip strength is a predictor of osteoporotic fractures: cross-sectional and prospective evidence from the Hong Kong Osteoporosis Study. Age 34, 1239–1248 (2012). 5. Kärkkäinen, M. et al. Association between functional capacity tests and fractures: an eight-year prospective population-based cohort study. Osteoporos. Int. 19, 1203–1210 (2008).
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