Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange-Reference-Cited by-同舟云学术

Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange

Published:2017-07-14 Issue:1 Volume:8 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Guillard Sandrine,Kolasinska-Zwierz Paulina,Debreczeni Judit,Breed Jason,Zhang Jing,Bery Nicolas^ORCID,Marwood Rose,Tart Jon,Overman Ross,Stocki Pawel,Mistry Bina,Phillips Christopher,Rabbitts Terence,Jackson Ronald,Minter Ralph^ORCID

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms16111.pdf

Reference43 articles.

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3. Cox, A. D., Fesik, S. W., Kimmelman, A. C., Luo, J. & Der, C. J. Drugging the undruggable RAS: mission possible? Nat. Rev. Drug Discov. 13, 828–851 (2014).

4. Hobbs, G. A., Der, C. J. & Rossman, K. L. RAS isoforms and mutations in cancer at a glance. J. Cell. Sci. 129, 1287–1292 (2016).

5. Bos, J. L., Rehmann, H. & Wittinghofer, A. GEFs and GAPs: critical elements in the control of small G proteins. Cell 129, 865–877 (2007).

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