Inhibition of JAK3 with a novel, selective and orally active small molecule induces therapeutic response in T-cell malignancies
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology,Cancer Research,Hematology
Link
http://www.nature.com/articles/leu2013309.pdf
Reference15 articles.
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3. Bains T, Heinrich MC, Loriaux MM, Beadling C, Nelson D, Warrick A et al. Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia. Leukemia 2012; 26: 2144–2146.
4. Cornejo MG, Kharas MG, Werneck MB, Le Bras S, Moore SA, Ball B et al. Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models. Blood 2009; 113: 2746–2754.
5. Lai R, Rassidakis GZ, Lin Q, Atwell C, Medeiros LJ, Amin HM . Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma. Hum Pathol 2005; 36: 939–944.
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