Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia-Reference-Cited by-同舟云学术

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Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia

Published:2013-08-08 Issue:1 Volume:28 Page:179-182
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Martins L R,Lúcio P,Melão A,Antunes I,Cardoso B A,Stansfield R,Bertilaccio M T S,Ghia P,Drygin D,Silva M G,Barata J T

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/leu2013232.pdf

Reference15 articles.

1. Gribben JG, O'Brien S . Update on therapy of chronic lymphocytic leukemia. J Clin Oncol 2011; 29: 544–550.

2. Faderl S, Ferrajoli A, Frankfurt O, Pettitt A . Treatment of B-cell chronic lymphocytic leukemia with nonchemotherapeutic agents: experience with single-agent and combination therapy. Leukemia 2009; 23: 457–466.

3. Piazza F, Manni S, Ruzzene M, Pinna LA, Gurrieri C, Semenzato G . Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways. Leukemia 2012; 26: 1174–1179.

4. Martins LR, Lucio P, Silva MC, Anderes KL, Gameiro P, Silva MG et al. Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia. Blood 2010; 116: 2724–2731.

5. Shehata M, Schnabl S, Demirtas D, Hilgarth M, Hubmann R, Ponath E et al. Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia. Blood 2010; 116: 2513–2521.

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