Why do people seek out polygenic risk scores for complex disorders, and how do they understand and react to results?

Author:

Peck Larissa,Borle KennedyORCID,Folkersen LasseORCID,Austin JehannineORCID

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Genetics

Reference27 articles.

1. Torkamani A, Wineinger NE, Topol EJ. The personal and clinical utility of polygenic risk scores. Nat Rev Genet. 2018;19:581–90.

2. Lewis CM, Vassos E. Prospects for using risk scores in polygenic medicine. Genome Med. 2017;9:96.

3. NorthShore University HealthSystem. Prostate Cancer Genetic Risk Score. 2016. https://www.helix.com/products/prostate-cancer-genetic-risk-score (accessed 15 Nov 2019).

4. Multhaup ML, Kita R, Krock B, Eriksson N, Fontanillas P, Aslibekyan S, et al. White Paper 23-19: The science behind 23andMe’s Type 2 Diabetes report. 2019. https://permalinks.23andme.com/pdf/23_19-Type2Diabetes_March2019.pdf

5. Janssens ACJW. Proprietary algorithms for polygenic risk: protecting scientific innovation or hiding the lack of it? Genes. 2019;10:448.

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