Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer

Author:

Blanco-Míguez AitorORCID,Carloni Sara,Cardenas Cindy,Dioguardi Carola Conca,Lambroia LucaORCID,Capretti Giovanni,Nappo Gennaro,Fugazza Alessandro,Capogreco Antonio,Armanini Federica,Asnicar FrancescoORCID,Dubois Leonard,Golzato Davide,Manghi PaoloORCID,Pinto Federica,Scuderi Cristina,Casari Erminia,Montorsi Marco,Anderloni Andrea,Rescigno MariaORCID,Repici Alessandro,Zerbi Alessandro,Peano Clelia,Tamburini SabrinaORCID,Rusconi RobertoORCID,Segata NicolaORCID

Abstract

AbstractMalignant bile duct obstruction is typically treated by biliary stenting, which however increases the risk of bacterial infections. Here, we analyzed the microbial content of the biliary stents from 56 patients finding widespread microbial colonization. Seventeen of 36 prevalent stent species are common oral microbiome members, associate with disease conditions when present in the gut, and include dozens of biofilm- and antimicrobial resistance-related genes. This work provides an overview of the microbial communities populating the stents.

Publisher

Springer Science and Business Media LLC

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