Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
http://www.nature.com/articles/nm.4499.pdf
Reference41 articles.
1. Sawyers, C.L. Chronic myeloid leukemia. N. Engl. J. Med. 340, 1330–1340 (1999).
2. Zhang, B. et al. Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia. Cancer Cell 21, 577–592 (2012).
3. Chu, S. et al. Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment. Blood 118, 5565–5572 (2011).
4. Lechman, E.R. et al. Attenuation of miR-126 activity expands HSC in vivo without exhaustion. Cell Stem Cell 11, 799–811 (2012).
5. de Leeuw, D.C. et al. Attenuation of microRNA-126 expression that drives CD34+38− stem–progenitor cells in acute myeloid leukemia leads to tumor eradication. Cancer Res. 74, 2094–2105 (2014).
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