Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A-Reference-Cited by-同舟云学术

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A

Published:2015-11 Issue:7577 Volume:527 Page:245-248
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Sun Jin-Hua,O’Boyle II Donald R.,Fridell Robert A.,Langley David R.,Wang Chunfu,Roberts Susan B.,Nower Peter,Johnson Benjamin M.,Moulin Frederic,Nophsker Michelle J.,Wang Ying-Kai,Liu Mengping,Rigat Karen,Tu Yong,Hewawasam Piyasena,Kadow John,Meanwell Nicholas A.,Cockett Mark,Lemm Julie A.,Kramer Melissa,Belema Makonen,Gao Min

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature15711.pdf

Reference28 articles.

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2. Shepard, C. W., Finelli, L. & Alter, M. J. Global epidemiology of hepatitis C virus infection. Lancet Infect. Dis. 5, 558–567 (2005)

3. Pawlotsky, J. M. NS5A inhibitors in the treatment of hepatitis C. J. Hepatol . 59, 375–382 (2013)

4. Guedj, J. et al. Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life. Proc. Natl Acad. Sci. USA 110, 3991–3996 (2013)

5. Macdonald, A. & Harris, M. Hepatitis C virus NS5A: tales of a promiscuous protein. J. Gen. Virol. 85, 2485–2502 (2004)

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