Identification of clinically relevant biomarkers of epileptogenesis — a strategic roadmap-Reference-Cited by-同舟云学术

Identification of clinically relevant biomarkers of epileptogenesis — a strategic roadmap

Published:2021-02-16 Issue:4 Volume:17 Page:231-242
ISSN:1759-4758
Container-title:Nature Reviews Neurology
language:en
Short-container-title:Nat Rev Neurol

Author:

Simonato Michele^ORCID,Agoston Denes V.,Brooks-Kayal Amy,Dulla Chris^ORCID,Fureman Brandy^ORCID,Henshall David C.^ORCID,Pitkänen Asla,Theodore William H.,Twyman Roy E.^ORCID,Kobeissy Firas H.^ORCID,Wang Kevin K.,Whittemore Vicky,Wilcox Karen S.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology (clinical)

Link

http://www.nature.com/articles/s41582-021-00461-4.pdf

Reference107 articles.

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2. Pitkanen, A. & Lukasiuk, K. Mechanisms of epileptogenesis and potential treatment targets. Lancet Neurol. 10, 173–186 (2011).

3. GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 18, 56–87 (2019).

4. Simonato, M. et al. The challenge and promise of anti-epileptic therapy development in animal models. Lancet Neurol. 13, 949–960 (2014). This review highlights the need for biomarker identification to develop disease-modifying therapies of epilepsy.

5. Loscher, W. & Schmidt, D. Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia 52, 657–678 (2011). This study shows that newer anti-epileptic drugs have provided limited improvements over the older ones.

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