Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Clinical Neurology
Link
http://www.nature.com/articles/s41582-019-0217-x.pdf
Reference168 articles.
1. Devinsky, O. et al. Epilepsy. Nat. Rev. Dis. Primer 4, 18024 (2018). This paper provides a detailed overview of the epilepsies, focusing on diagnosis, treatments, pathophysiology, animal models and biomarkers.
2. Scheffer, I. E. et al. ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia 58, 512–521 (2017).
3. van Vliet, E. A., Aronica, E., Vezzani, A. & Ravizza, T. Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies. Neuropathol. Appl. Neurobiol. 44, 91–111 (2018). This article provides an extensive review of the inflammatory targets characterized in animal models of epilepsy for drug development.
4. Aronica, E. et al. Neuroinflammatory targets and treatments for epilepsy validated in experimental models. Epilepsia 58 (Suppl. 3), 27–38 (2017).
5. Vezzani, A., Lang, B. & Aronica, E. Immunity and inflammation in epilepsy. Cold Spring Harb. Perspect. Med. 6, a022699 (2015). This paper provides a review of the involvement of innate and adaptive immune mechanisms in the pathogenesis of seizures in autoimmune and common forms of epilepsy.
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