Early neurotrophic pharmacotherapy rescues developmental delay and Alzheimer’s-like memory deficits in the Ts65Dn mouse model of Down syndrome
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep45561.pdf
Reference161 articles.
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2. Wiseman, F. K. et al. A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome. Nature reviews. Neuroscience 16, 564–574, doi: 10.1038/nrn3983 (2015).
3. Isacson, O., Seo, H., Lin, L., Albeck, D. & Granholm, A. C. Alzheimer’s disease and Down’s syndrome: roles of APP, trophic factors and ACh. Trends Neurosci 25, 79–84 (2002).
4. Mann, D. M. & Esiri, M. M. The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down’s syndrome. J Neurol Sci 89, 169–179 (1989).
5. Wisniewski, K. E., Dalton, A. J., McLachlan, C., Wen, G. Y. & Wisniewski, H. M. Alzheimer’s disease in Down’s syndrome: clinicopathologic studies. Neurology 35, 957–961 (1985).
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