Accelerating the search for the missing proteins in the human proteome-Reference-Cited by-同舟云学术

Accelerating the search for the missing proteins in the human proteome

Published:2017-01-24 Issue:1 Volume:8 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Baker Mark S.^ORCID,Ahn Seong Beom,Mohamedali Abidali,Islam Mohammad T.^ORCID,Cantor David,Verhaert Peter D.,Fanayan Susan,Sharma Samridhi,Nice Edouard C.,Connor Mark^ORCID,Ranganathan Shoba

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms14271.pdf

Reference58 articles.

1. Paik, Y. K. et al. The Chromosome-centric Human Proteome Project for cataloging proteins encoded in the genome. Nat. Biotechnol. 30, 221–223 (2012) Aims to define full set of human proteins encoded by ∼20,300 genes, chromosome-by-chromosome including tissue localization, isoforms and PTMs using MS and Abs. First coined term ‘missing proteins’.

2. Paik, Y. K. et al. Standard guidelines for the Chromosome-centric Human Proteome Project. J. Proteome Res. 11, 2005–2013 (2012).

3. Legrain, P. et al. The Human Proteome Project: current state and future direction. Mol. Cell Proteomics 10, M111.009993 (2011).

4. Omenn, G. S. et al. Metrics for the Human Proteome Project 2015: progress on the Human Proteome and Guidelines for High-confidence Protein Identification. J. Proteome Res. 14, 3452–3460 (2015).

5. Omenn, G. S. et al. Metrics for the Human Proteome Project 2016: progress on identifying and characterizing the human proteome, including post-translational modifications. J. Proteome Res. 15, 3951–3960 (2016) Update on HPP annual communal data re-analyses that adopted higher stringency MS metrics for protein evidence (PE1 = two unitypic peptides > 9 residues). HPP (neXtProt version 2016-02) has 16,518 PE1 proteins, with 2,949 PE2-4 missing proteins and 485 reclassified by higher stringency HPP Guidelines v2.0 to reduce false positives.

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