T-LAK cell-originated protein kinase (TOPK): an emerging target for cancer-specific therapeutics
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology
Link
http://www.nature.com/articles/s41419-018-1131-7.pdf
Reference67 articles.
1. Abe, Y., Matsumoto, S., Kito, K. & Ueda, N. Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. J. Biol. Chem. 275, 21525–21531 (2000).
2. Oh, S. M. et al. T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation. Cancer Res. 67, 5186–5194 (2007).
3. Zhu, F. et al. Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells. Gastroenterology 133, 219–231 (2007).
4. Aksamitiene, E., Kholodenko, B. N., Kolch, W., Hoek, J. B. & Kiyatkin, A. PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells. Cell. Signal. 22, 1369–1378 (2010).
5. Ayllon, V. & O’Connor, R. PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response. Oncogene 26, 3451–3461 (2007).
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1. Comprehensive analysis of the potential pathogenesis of COVID-19 infection and liver cancer;World Journal of Gastrointestinal Oncology;2024-02-15
2. TOPK promotes the development of psoriasis and worenine alleviates psoriasiform dermatitis by inhibiting TOPK activity;Journal of the European Academy of Dermatology and Venereology;2023-12-22
3. Comprehensive Physicochemical Characterization, In Vitro Membrane Permeation, and In Vitro Human Skin Cell Culture of a Novel TOPK Inhibitor, HI-TOPK-032;International Journal of Molecular Sciences;2023-10-24
4. Polyphyllin VII induces autophagy‐dependent ferroptosis in human gastric cancer through targeting T‐lymphokine‐activated killer cell‐originated protein kinase;Phytotherapy Research;2023-08-26
5. Topical application of TOPK inhibitor OTS514 suppresses psoriatic progression by inducing keratinocytes cell cycle arrest and apoptosis;Experimental Dermatology;2023-08-14
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