Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM

Author:

Przystal Justyna Magdalena,Hajji Nabil,Khozoie Combiz,Renziehausen Alexander,Zeng Qingyu,Abaitua Fernando,Hajitou Amin,Suwan Keittisak,Want Elizabeth,Bomalaski John,Szlosarek Peter,O’Neill Kevin,Crook Tim,Syed Nelofer

Funder

Brain Tumour Research Campaign UK Brain Tumour Research UK

Brain Tumour Research Campaign Brain Tumour Research

Barrow Neurological Institute

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology

Reference32 articles.

1. Thomas, R. P., Recht, L. & Nagpal, S. Advances in the management of glioblastoma: the role of temozolomide and MGMT testing. Clin. Pharmacol. 5, 1–9 (2013).

2. Moren, L. et al. Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM. BMC Cancer 18, 167 (2018).

3. Syed, N. et al. Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma. Cell Death Dis. 4, e458 (2013).

4. Gong, H., Zolzer, F., von Recklinghausen, G., Havers, W. & Schweigerer, L. Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cycle arrest and apoptosis. Leukemia 14, 826–829 (2000).

5. Ensor, C. M., Holtsberg, F. W., Bomalaski, J. S. & Clark, M. A. Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo. Cancer Res. 62, 5443–5450 (2002).

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