XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis-Reference-Cited by-同舟云学术

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XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis

Published:2019-05-21 Issue:6 Volume:10 Page:
ISSN:2041-4889
Container-title:Cell Death & Disease
language:en
Short-container-title:Cell Death Dis

Author:

Zhu Zhi-Chuan,Liu Ji-Wei,Yang Can,Zhao Miao,Xiong Zhi-Qi

Funder

Science and Technology Commission of Shanghai Municipality

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology

Link

http://www.nature.com/articles/s41419-019-1627-9.pdf

Reference37 articles.

1. Hutten, S. & Kehlenbach, R. H. CRM1-mediated nuclear export: to the pore and beyond. Trends Cell Biol. 17, 193–201 (2007).

2. Kazim, S. et al. Selective nuclear export inhibitor KPT-330 enhances the antitumor activity of gemcitabine in human pancreatic cancer. Mol. Cancer Ther. 14, 1570–1581 (2015).

3. Kim, J. et al. XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer. Nature 538, 114–117 (2016).

4. Camus, V., Miloudi, H., Taly, A., Sola, B. & Jardin, F. XPO1 in B cell hematological malignancies: from recurrent somatic mutations to targeted therapy. J. Hematol. Oncol. 10, 47 (2017).

5. Chen, C. et al. Safety and efficacy of selinexor in relapsed or refractory multiple myeloma and waldenstrom macroglobulinemia. Blood 131, 855–863 (2018).

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