TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration

Author:

Grolez Guillaume P.ORCID,Gordiendko Dmitri V.,Clarisse Manon,Hammadi Mehdi,Desruelles Emilie,Fromont Gaëlle,Prevarskaya NataliaORCID,Slomianny Christian,Gkika DimitraORCID

Abstract

AbstractIn prostate carcinogenesis, androgens are known to control the expression of the transient receptor potential melastatin 8 (TRPM8) protein via activation of androgen receptor (AR). Overexpression and/or activity of TRPM8 channel was shown to suppress prostate cancer (PCa) cell migration. Here we report that at certain concentrations androgens facilitate PCa cell migration. We show that underlying mechanism is inhibition of TRPM8 by activated AR which interacts with the channel within lipid rafts microdomains of the plasma membrane. Thus, our study has identified an additional nongenomic mechanism of the TRPM8 channel regulation by androgens that should be taken into account upon the development of novel therapeutic strategies.

Funder

Institut National Du Cancer

Institut Universitaire de France

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology

Reference50 articles.

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