Grb2 binds to PTEN and regulates its nuclear translocation to maintain the genomic stability in DNA damage response
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology
Link
http://www.nature.com/articles/s41419-019-1762-3.pdf
Reference45 articles.
1. Schlessinger, J. Cell signaling by receptor tyrosine kinases. Cell 103, 211–225 (2000).
2. Di Fulvio, M., Henkels, K. M. & Gomez-Cambronero, J. Short-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesis. Biochem. Biophys. Res. Commun. 357, 737–742 (2007).
3. Timsah, Z. et al. Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene 35, 2186–2196 (2016).
4. Shen, W. H. et al. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128, 157–170 (2007).
5. Kao, G. D., Jiang, Z., Fernandes, A. M., Gupta, A. K. & Maity, A. Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation. J. Biol. Chem. 282, 21206–21212 (2007).
Cited by 28 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. GRB2: A dynamic adaptor protein orchestrating cellular signaling in health and disease;Biochemistry and Biophysics Reports;2024-09
2. PRMT7 mediated PTEN activation promotes bone formation in female mice;2024-07-31
3. Identification of differentially expressed autophagy-related genes in cases of intracranial aneurysm: Bioinformatics analysis;Journal of Stroke and Cerebrovascular Diseases;2024-06
4. Insights into Clinical Disorders in Cowden Syndrome: A Comprehensive Review;Medicina;2024-05-06
5. GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer;Nature Communications;2024-03-08
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3