Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions

Author:

Wasserman Michael R.,Pulk Arto,Zhou Zhou,Altman Roger B.,Zinder John C.,Green Keith D.,Garneau-Tsodikova Sylvie,Doudna Cate Jamie H.,Blanchard Scott C.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Reference70 articles.

1. Wang, L. et al. Allosteric control of the ribosome by small-molecule antibiotics. Nat. Struct. Mol. Biol. 19, 957–963 (2012).

2. Puglisi, J. D. et al. in The Ribosome: Structure, Function, Antibiotics and Cellular Interactions eds Garrett R. A., Douthwaite S. R., Liljas A., Matheson A. T., Moore P. B., Noller H. F. ASM Press (2000).

3. Cabanas, M. J., Vazquez, D. & Modolell, J. Inhibition of ribosomal translocation by aminoglycoside antibiotics. Biochem. Biophys. Res. Commun. 83, 991–997 (1978).

4. Davies, J., Gorini, L. & Davis, B. D. Misreading of RNA codewords induced by aminoglycoside antibiotics. Mol. Pharmacol. 1, 93–106 (1965).

5. Peske, F., Savelsbergh, A., Katunin, V. I., Rodnina, M. V. & Wintermeyer, W. Conformational changes of the small ribosomal subunit during elongation factor G-dependent tRNA-mRNA translocation. J. Mol. Biol. 343, 1183–1194 (2004).

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