Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep38694.pdf
Reference56 articles.
1. Dawson, S., Stahl, S., Paul, N., Barber, J. & Kenna, J. G. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug Metab. Dispos. 40, 130–138, doi: 10.1124/dmd.111.040758 (2012).
2. Susukida, T., Sekine, S., Nozaki, M., Tokizono, M. & Ito, K. Prediction of the clinical risk of drug-induced cholestatic liver injury using an in vitro sandwich cultured hepatocyte assay. Drug Metab. Dispos. 43, 1760–1768, doi: 10.1124/dmd.115.065425 (2015).
3. Woodhead, J. L. et al. Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury. Front. Pharmacol. 5, 240, doi: 10.3389/fphar.2014.00240 (2014).
4. Perez, M. J. & Briz, O. Bile-acid-induced cell injury and protection. World J. Gastroenterol. 15, 1677–1689 (2009).
5. Schulz, S. et al. Progressive stages of mitochondrial destruction caused by cell toxic bile salts. Biochim. Biophys. Acta 1828, 2121–2133, doi: 10.1016/j.bbamem.2013.05.007 (2013).
Cited by 31 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Establishment of human induced pluripotent stem cell-derived hepatobiliary organoid with bile duct for pharmaceutical research use;Biomaterials;2024-10
2. Human-Induced Hepatocytes-Derived Extracellular Vesicles Ameliorated Liver Fibrosis in Mice Via Suppression of TGF-β1/Smad Signaling and Activation of Nrf2/HO-1 Signaling;Stem Cells and Development;2023-10-01
3. The evolving role of investigative toxicology in the pharmaceutical industry;Nature Reviews Drug Discovery;2023-02-13
4. Limitations and challenges of direct cell reprogramming in vitro and in vivo;HISTOL HISTOPATHOL;2022
5. Human iPSC-derived hepatocyte system models cholestasis with tight junction protein 2 deficiency;JHEP Reports;2022-04
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3