Two single amino acid substitutions in the intervening region of Newcastle disease virus HN protein attenuate viral replication and pathogenicity
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep13038.pdf
Reference28 articles.
1. Aldous, E. W. & Alexander, D. J. Newcastle disease in pheasants (Phasianus colchicus): a review. Vet J 175, 181–185 (2008).
2. Cornax, I. et al. Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host range. J Gen Virol 94, 1189–1194 (2013).
3. Kim, S. H. et al. Mutations in the fusion protein cleavage site of avian paramyxovirus serotype 4 confer increased replication and syncytium formation in vitro but not increased replication and pathogenicity in chickens and ducks. Plos One 8, e50598 (2013).
4. Huang, Z. et al. The hemagglutinin-neuraminidase protein of Newcastle disease virus determines tropism and virulence. J Virol 78, 4176–4184 (2004).
5. Yuan, P. et al. Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk. Proc Natl Acad Sci USA 108, 14920–14925 (2011).
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