Is long-term glucocorticoid therapy associated with a high prevalence of asymptomatic vertebral fractures?
Author:
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Link
http://www.nature.com/articles/ncpendmet0372.pdf
Reference5 articles.
1. LoCascio V et al. (1990) Bone loss in response to long-term glucocorticoid therapy. Bone Miner 8: 39–51
2. Van Staa TP et al. (2003) Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy. Arthritis Rheum 48: 3224–3229
3. Weinstein RS et al. (1998) Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids: potential mechanisms of their deleterious effects on bone. J Clin Invest 102: 274–282
4. O'Brien CA et al. (2004) Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology 145: 1835–1841
5. Weinstein RS (2001) Glucocorticoid-induced osteoporosis. Rev Endocr Metab Disord 2: 65–73
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